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KMID : 0878220150270020240
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Journal of Sasang Constitutional Medicine
2015 Volume.27 No. 2 p.240 ~ p.253
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The Effects of GalGunSeunggi-tang (GST) on Mice Induced Allergic Contact Dermatitis (ACD) by DNCB
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Lim Tae-Hyung
Park Hye-Sun
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Abstract
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Objectives: The aim of this study was to investigate the effects of GalGunSeungGi-Tang (GST) on allergic contact dermatitis (ACD) induced by 2,4-dintrochlorobenzone (DNCB)
Methods : In this study, The changes of body weight, ear weight, ear thickness, spleen weight, dorsum skin thickness, symptom score by eyesight, histological finding, proliferation rates of splenocyte in vitro and in vivo are investigated to check effects of GST. The mice are divided into four group; Normal (naive mice) , Control (DW administered), GST-L (GST 500mg/Kg/day administered), GST-H (GST 1,000mg/Kg/day administered).
Results : GST inhibited weight of ear significantly (P < 0.05) and also thickness (P < 0.01). In addition, There are significant decrease in thickness of dorsum skin and proliferation rates of splenocyte in vivo in GST administered group. Finally, GST reduced symptom score and hyperkeratosis, hyperpigmentation, increase of granulocyte and parakeratosis in histological finding.
Conclusions: These results suggest that GST can decrease symptoms of ACD.
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KEYWORD
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Sasang Constitutional Medicine, GalGunSeungGi-Tang, Allergic Contact Dermatitis, DNCB
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